What is Malaria Diseases
Malaria diseases is typically found in tropical and subtropical climates where the parasites can live. Once the parasites are inside your body, they travel to the liver, where they mature. After several days, the mature parasites enter the bloodstream and begin to infect red blood cells. Within 48 to 72 hours, the parasites inside the red blood cells multiply, causing the infected cells to burst open. The parasites continue to infect red blood cells, resulting in symptoms that occur in cycles that last two to three days at a time.The World Health Organization estimates that about 3.2 billions people are at risk of malaria.
Malaria can occur if a mosquito infected with the Plasmodium parasite bites you. An infected mother can also pass the disease to her baby at birth. This is known as congenital malaria. Malaria can cause a number of life-threatening complications. People with malaria who receive treatment typically have a good long-term outlook. If complications arise as a result of malaria, the outlook may not be as good.
About Cerebral Malaria
Cerebral malaria, which causes swelling of the blood vessels of the brain, can result in brain damage. The long-term outlook for patients with drug-resistant parasites may also be poor. In these patients, malaria may recur. This may cause other complications. All the clinical symptoms associated with malaria are caused by the asexual erythrocytic or blood stage parasites. When the parasite develops in the erythrocyte, numerous known and unknown waste substances such as hemozoin pigment and other toxic factors accumulate in the infected red blood cell.
These are dumped into the bloodstream when the infected cells lyse and release invasive merozoites. The hemozoin and other toxic factors such as glucose phosphate isomerase stimulate macrophages and other cells to produce cytokines and other soluble factors which act to produce fever and rigors and probably influence other severe pathophysiology associated with malaria.